Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 6, Pages 1858-1871Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202798
Keywords
catalysis; CC coupling; enantioselectivity; enolates; natural products; nickel; palladium
Categories
Funding
- Science Council (Vetenskapsradet, Sweden)
- Gothenburg University, Stockholm University
- Royal Institute of Technology (Stockholm)
- National Science Foundation (USA)
- AstraZeneca
- Ara Parseghian Medical Research Foundation
- Charles Edison Foundation
- University of Notre Dame
Ask authors/readers for more resources
Transition-metal-catalyzed alkenylation of enolates provides a direct method to synthesize broadly useful ,-unsaturated carbonyl compounds from the corresponding carbonyl compound and alkenyl halides. Despite being reported in the early seventies, this reaction class saw little development for many years. In the past decade, however, efforts to develop this reaction further have increased considerably, and many research groups have reported efficient coupling protocols, including enantioselective versions. These reactions most commonly employ palladium catalysts, but there are also some important reports using nickel. There are many examples of this powerful transformation being used in the synthesis of complex natural products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available