Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 17, Pages 5332-5341Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203886
Keywords
adsorption; drug delivery; microwave chemistry; nanostructures; proteins
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Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [51172260, 51102258, 51121064]
- Science and Technology Commission of Shanghai [11nm0506600]
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure
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Hierarchically nanostructured porous hollow microspheres of hydroxyapatite (HAP) are a promising biomaterial, owing to their excellent biocompatibility and porous hollow structure. Traditionally, synthetic hydroxyapatite is prepared by using an inorganic phosphorus source. Herein, we report a new strategy for the rapid, sustainable synthesis of HAP hierarchically nanostructured porous hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through a microwave-assisted hydrothermal method. The as-obtained products are characterized by powder X-ray diffraction (XRD), Fourier-transform IR (FTIR) spectroscopy, SEM, TEM, BrunauerEmmettTeller (BET) nitrogen sorptometry, dynamic light scattering (DLS), and thermogravimetric analysis (TGA). SEM and TEM micrographs show that HAP hierarchically nanostructured porous hollow microspheres consist of HAP nanosheets or nanorods as the building blocks and DLS measurements show that the diameters of HAP hollow microspheres are within the range 0.81.5m. The specific surface area and average pore size of the HAP porous hollow microspheres are 87.3m2g1 and 20.6nm, respectively. The important role of creatine phosphate disodium salt and the influence of the experimental conditions on the products were systematically investigated. This method is facile, rapid, surfactant-free and environmentally friendly. The as-prepared HAP porous hollow microspheres show a relatively high drug-loading capacity and protein-adsorption ability, as well as sustained drug and protein release, by using ibuprofen as a model drug and hemoglobin (Hb) as a model protein, respectively. These experiments indicate that the as-prepared HAP porous hollow microspheres are promising for applications in biomedical fields, such as drug delivery and protein adsorption.
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