Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 38, Pages 12739-12747Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201300791
Keywords
DNA; G-quadruplexes; G-quartets; RNA; supramolecular chemistry
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Universite de Bourgogne (uB)
- Conseil Regional de Bourgogne (CRB)
- Agence Nationale de la Recherche (ANR) [ANR-10-JCJC-0709, PARI-SSTIC 6 (92-01)]
- Agence Nationale de la Recherche (ANR) [ANR-10-JCJC-0709] Funding Source: Agence Nationale de la Recherche (ANR)
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Natural G-quartets, a cyclic and coplanar array of four guanine residues held together through a Watson-Crick/Hoogsteen hydrogen-bond network, have received recently much attention due to their involvement in G-quadruplex DNA, an alternative higher-order DNA structure strongly suspected to play important roles in key cellular events. Besides this, synthetic G-quartets (SQ), which artificially mimic native G-quartets, have also been widely studied for their involvement in nanotechnological applications (i.e., nanowires, artificial ion channels, etc.). In contrast, intramolecular synthetic G-quartets (iSQ), also named template-assembled synthetic G-quartets (TASQ), have been more sparingly investigated, despite a technological potential just as interesting. Herein, we report on a particular iSQ named (PNA)DOTASQ, which demonstrates very interesting properties in terms of DNA and RNA interaction (notably its selective recognition of quadruplexes according to a bioinspired process) and catalytic activities, through its ability to perform peroxidase-like hemin-mediated oxidations either in an autonomous fashion (i.e., as pre-catalyst for TASQzyme reactions) or in conjunction with quadruplex DNA (i.e., as enhancing agents for DNAzyme processes). These results provide a solid scientific basis for TASQ to be used as multitasking tools for bionanotechnological applications.
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