Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 33, Pages 10786-10793Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201301324
Keywords
discotics; molecular imaging; self-assembly; supramolecular chemical biology; supramolecular chemistry
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Funding
- Ministry of Education, Culture and Science [024.001.035]
- ERC [310275-BioNLight, CTMM-03O-201 Mammoth]
- STW [11022-NanoActuate]
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Self-assembly of discotic molecules into supramolecular polymers offers a flexible approach for the generation of multicomponent one-dimensional columnar architectures with tuneable biomedical properties. Decoration with ligands induces specific binding of the self-assembled scaffold to biological targets. The modular design allows the easy co-assembly of different discotics for the generation of probes for targeted imaging and cellular targeting with adjustable ligand density and composition.
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