Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 2, Pages 410-415Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303613
Keywords
domino reactions; enantioselectivity; glutarimides; organocatalysis; spiroannulation
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Funding
- Agence Nationale pour la Recherche [ANR-11-BS07-0014]
- Centre National de la Recherche Scientifique (CNRS)
- COST Action [CM0905]
- Aix-Marseille Universite
- Agence Nationale de la Recherche (ANR) [ANR-11-BS07-0014] Funding Source: Agence Nationale de la Recherche (ANR)
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alpha, beta-Unsaturated acyl cyanides are key bis-electrophile substrates for successful domino enantioselective organocatalyzed Michael-intramolecular acylation domino sequences. This new reactivity has been applied to the synthesis of enantioenriched azaspiro[4,5] decanone ring systems by a formal [3+ 3] spiroannulation, constituting a rare example of synthesis of glutarimides in an optically active form.
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