Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 18, Issue 35, Pages 10786-10801Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201103069
Keywords
acceptor specificity; enzyme engineering; glycosylation; glycosyltransferase; high-throughput screening
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Funding
- EC through FP7-project Novosides [KBBE-4-265854]
- Carl-Zeiss foundation
- Fonds der chemischen Industrie (FCI)
- Carbohydrate Competence Center
- Multidisciplinary Research Partnership Ghent Bio-Economy
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Glycosylation can significantly improve the physicochemical and biological properties of small molecules like vitamins, antibiotics, flavors, and fragrances. The chemical synthesis of glycosides is, however, far from trivial and involves multistep routes that generate lots of waste. In this review, biocatalytic alternatives are presented that offer both stricter specificities and higher yields. The advantages and disadvantages of different enzyme classes are discussed and illustrated with a number of recent examples. Progress in the field of enzyme engineering and screening are expected to result in new applications of biocatalytic glycosylation reactions in various industrial sectors.
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