Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 19, Issue 1, Pages 92-95Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203344
Keywords
DNAzyme; DSN enzyme; nucleic acids; RNA; peroxidases
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Funding
- National Basic Research Program of China (973 Program) [2012CB720600, 2012CB720603, 2012CB720605]
- National Science of Foundation of China [91213302, 30973605, 21072115]
- National Grand Program on Key Infectious Disease [2012ZX10003002-014]
- Open Funding of the State Key Laboratory of Bioorganic and Natural Products Chemistry
- Shanghai Institute of Organic Chemistry
- Chinese Academy of Sciences
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]
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On target: We have developed two cascade amplification strategies that combine duplex specific nuclease (DSN) amplicon with either G-quadruplex-based DNA peroxidase or 8-17 DNAzyme amplicon for miRNA detection. In this way, sensitive and convenient detection of miRNAs was achieved. In the DNA peroxidase-based system, a visual color change could be observed in the presence of target miRNAs (see scheme).
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