Synthesis and Anti-inflammatory Screening of Some Mono and Bis-Alkoxyphthalimide Linked Benzimidazole and their Quinazoline and Pyrimidine Derivatives

In the present study, synthesis of some nonsymmetrical 2-(1H-benzimidazol-2-ylamino)-7,7-dimethyl7,8-dihydroquinazolin-5(6H)-one (3) and substituted-(1H-benzo[d] imidazol-2-yl) amino-pyrimidine derivatives (4a-c and 5a-b) is described as a three-component reaction of 2-guanidinobenzimidazole (2) with triethyl orthoformate and different reactive methylene compounds. Subsequent condensation of compounds 3, 4a-c, and 5a-b with bromoethoxyphthalimide (1) gave final compounds 6, 7a-c, and 8a-b. Synthesized final compounds have been screened for their in-vivo anti-inflammatory activity against carrageenan-induced paw edema in albino rats. Diclofenac was used as standard anti-inflammatory agents. Some of the compounds exhibited significant anti-inflammatory activity, as compared to standard drug. Structures of synthesized compounds have been confirmed on the basis of chemical tests and spectral studies.