Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 54, Issue 1, Pages 125-130Publisher
WILEY
DOI: 10.1002/jhet.2552
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Funding
- U.G.C., New Delhi, India
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Emergence of multidrug resistant and extensively drug resistant tuberculosis has prompted to develop new molecular entities to treat the disease. A series of new 4-thiazolidinones with pyrazinyl and thiazolyl scaffolds has been synthesized, and their antitubercular activity is reported. The title 4-thiazolidinones, N-( pyrazinyl substituted thiazoloylamino)-2-aryl-4-thiazolidinones (6a-j) have been first time prepared using pyrazinamide as a starting material via five successive steps. The purity and the structures of the intermediates (carboethoxythiazole, acid hydrazide, and azomethines) and title thiazolidinones (6a-j) have been confirmed by TLC and spectral analyses, respectively. An antitubercular screening of the new 4-thiazolidinones has been performed on bacterial strains, Mycobacterium tuberculosis H37Ra and Mycobacterium BCG using the solutions of different concentrations of the compounds (6a-j) and the screening results are presented. Compound 6a has displayed notable antitubercular activity.
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