Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 18, Issue 23, Pages 7082-7090Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201103611
Keywords
imaging agents; methylene blue; nanoparticles; photodynamic therapy; singlet oxygen
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Funding
- National Natural Science Foundation of China Research [50823007, 50972154, 51132009, 51072212, 51102259, 21172043]
- Science and Technology Commission of Shanghai [11nm0505000, 10430712800]
- National Basic Research Program of China (973 Program) [2011CB707905]
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Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well-selected bifunctional gadolinium (Gd)-ion-doped UCNPs and water-soluble methylene blue (MB) combined with the water-in-oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB-based PDT drug, NaYF4:Er/Yb/Gd@SiO2(MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug-formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as-designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near-infrared laser-triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging.
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