Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 18, Issue 47, Pages 14904-14917Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202831
Keywords
asymmetric synthesis; carbenes; cyclopropane; fluorine; fluoroalkenes; Michael reaction
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The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant building blocks for the discovery of efficient fluorinated biologically active agents. In this review, we report the different strategies to access monofluorocyclopropanes and highlight some of their attractive biological applications.
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