Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 18, Issue 50, Pages 15910-15920Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202697
Keywords
Alzheimer's disease; amyloid beta peptides; bioinorganic chemistry; neurochemistry; transition metals
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Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimers disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress.
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