Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 47, Pages 13284-13297Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201101993
Keywords
acidity; bimetallic bases; deprotonation; lithium; pyridines
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Funding
- Agence Nationale de la Recherche
- MESR of France
- Institut Universitaire de France and Rennes Metropole
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A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithiummetal combinations. Whereas lithiumzinc and lithiumcadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithiumcopper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.
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