Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 13, Pages 3768-3773Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002888
Keywords
asymmetric catalysis; copper; Henry reaction; N ligands; nucleophilic addition
Categories
Funding
- Ministerio de Ciencia e Innovacion
- FEDER [CTQ2006-14199, CTQ2009-13083]
- Generalitat Valenciana [ACOMP/2009/338]
- Universitat de Valencia
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The enantioselective Henry reaction between alkyl-and arylglyoxal hydrates and nitromethane catalyzed by Cu-II-iminopyridine complexes takes place regioselectively on the ketone carbonyl group to give chiral tertiary nitroaldols with high functional group density and enantiomeric excesses of up to 96%. Both aromatic and aliphatic glyoxals are suitable substrates for this reaction.
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