Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 5, Pages 1388-1408Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201001451
Keywords
alkaloids; heterocycles; natural products; peptides
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Funding
- PharmaMar (Madrid), CICYT [CTQ2009-07758/BQU]
- Institut de Salud Carlos III [CB06_01_0074]
- Generalitat de Catalunya [2009SGR 1024]
- Institute for Research in Biomedicine
- Barcelona Science Park
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Research on natural products containing hexahydropyrrolo[2,3-b]indole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HP1, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.
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