Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 6, Pages 1966-1971Publisher
WILEY-BLACKWELL
DOI: 10.1002/chem.201002634
Keywords
antitumor agents; dendrimers; drug delivery; host-guest systems; metallaprisms
Categories
Funding
- Swiss National Science Foundation [200020-129501]
Ask authors/readers for more resources
The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-containing dendrimers of different generations (P(0), P(1) and P(2)), affords the triangular prismatic host guest compounds [P(n)subset of Ru(6)(p-cymene)(6)(tpt)(2)(donq)(3)](6+) ([P(n)subset of 1](6+)). The host-guest nature of these systems, with the pyrenyl moiety being encapsulated in the hydrophobic cavity of the cage and the dendritic functional group pointing outwards, was confirmed by NMR spectroscopy ((1)H, 2D and DOSY). The host-guest properties of these systems were studied in solution by NMR and UV/Vis spectroscopic methods, allowing the determination of their affinity constants (K(a)). Moreover, the ability of these water-soluble host-guest systems to carry the pyrenyl-containing dendrimers into cancer cells was evaluated on human ovarian cancer cells. The host-guest systems are all more cytotoxic than the empty cage [1][CF(3)SO(3)](6) (IC(50) approximate to 4 mu M), with the most active compound, [P(0)subset of 1][CF(3)SO(3)](6), being an order of magnitude more cytotoxic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available