4.6 Article

Organocatalytic Michael-Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 10, Pages 2842-2845

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201003423

Keywords

asymmetric catalysis; cyclopropanation; Michael addition; quaternary stereocenters; spiro compounds

Funding

  1. Bologna University
  2. MIUR

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The spiro saga goes on! The title reaction sequence provides the first enantioselective synthesis of spiro nitrocyclopropyl oxindoles. The method provides easy access to these new, biologically inspired compounds from readily available starting materials (see scheme).

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