Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 45, Pages 12773-12783Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201100967
Keywords
alkynes; carbonickelation; domino reactions; nickel; vinylnickel
Categories
Funding
- Region de Haute-Normandie
- CRUNCh inter-regional program
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Carbonickelations of alkynes and functionalization of the resulting vinylnickel moiety have been performed efficiently in a nickel-catalyzed domino cyclization-condensation process. This reaction, which does not require the preparation of any other organometallic reagent, proceeds only by exo-dig cyclization. This convenient and mild method constitutes a one-pot synthesis of substituted dihydrobenzofurans, chromans, isochromans, indoles, or indanes. Theses valuable products are generally obtained in good yields and high stereoselectivity. They are shown to be useful synthons for rapid access to functionalized polycyclic skeletons.
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