Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 42, Pages 11752-11760Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201101066
Keywords
coumarin; dendrimers; enzymes; micelles; photochemistry
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Funding
- NIGMS NIH HHS [R01 GM065255, GM-065255] Funding Source: Medline
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Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme-responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non-covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo-crosslinking is also utilized as a tool to investigate the mode of enzyme-substrate interaction in the context of aggregate-monomer equilibrium.
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