Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 26, Pages 7366-7373Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201003679
Keywords
biotemplating; imaging agents; magnetic nanowires; nano-structures; protein fibrils
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Funding
- Ministerio de Ciencia e Innovacion (MICINN) [MAT 2010-17336]
- Xunta de Galicia [INCITE09206020PR]
- European Regional Development Funds [2010/50]
- Fundacion Ramon Areces
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Magnetic nanowires were obtained through the in situ synthesis of magnetic material by Fecontrolled nanoprecipitation in the presence of two different protein (human serum albumin (HSA) and lysozyme (Lys)) fibrils as biotemplating agents. The structural characteristics of the biotemplates were transferred to the hybrid magnetic wires. They exhibited excellent magnetic properties as a consequence of the 1D assembly and fusion of magnetite nanoparticles as ascertained by SQUID magnetometry. Prompted by these findings, we also checked their potential applicability as MRI contrast agents. The magnetic wires exhibited large r(2)* relaxivities and sufficient contrast resolution even in the presence of an extremely small amount of Fe in the magnetic hybrids, which would potentially enable their use as T-2 contrast imaging agents.
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