Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 29, Pages 8209-8215Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201100272
Keywords
circular dichroism; DNA; G-quadruplex; induction; supramolecular chemistry
Categories
Funding
- 973 Project [2011CB936004]
- NSFC [20831003, 90813001, 20833006, 90913007]
- Chinese Academy of Sciences
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Chiral molecular recognition of human telomeric DNA is important for rational drug design and developing structural probes of G-quadruplexes. Here we report that a chiral supramolecular complex can selectively induce human telomeric G-quadruplex formation and discriminate different G-quadruplex sequences under salt-deficient conditions studied by circular dichroism (CD), UV meltings, stopped-flow spectroscopy, fluorescence resonance energy transfer, enzyme cleavage, and gel electrophoresis. P-enantiomer induced G-quadruplex formation is fast and does not require a large excess of P enantiomer. More importantly, this chiral compound induces loop sequence-dependent G-quadruplex formation.
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