Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 9, Pages 2716-2723Publisher
WILEY-BLACKWELL
DOI: 10.1002/chem.201002661
Keywords
copper; cross-coupling; mass spectrometry; N ligands; reactive intermediates
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Funding
- National Science Council, Republic of China
- Academia Sinica
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Complex [Na(phen)(3)][Cu(NPh2)(2)] (2), containing a linear bis(N-phenylanilide) copper(I) anion and a distorted octahedral tris(1,10-phenanthroline) sodium counter cation, has been isolated from the catalytic C-N cross-coupling reaction with the CuI/phen/tBuONa (phen=1,10-phenanthroline) catalytic system. Complex 2 can react with 4-iodotoluene to produce 4-methyl-N,N-diphenylaniline 3a) with 70.6% yield. In addition, 2 can work as an effective catalyst for C-N coupling under the same reaction conditions, thus indicating that 2 is the intermediate of the catalytic system. Both [Cu(NPh2)(2)](-) and [Cu(NPh2)I](-) have been observed by in situ electron ionization mass spectrometry (ESI-MS) under catalytic reaction conditions, thus confirming that they are intermediates in the reaction. A catalytic cycle has been proposed based on these observations. The molecular structure of 2 has been determined by single-crystal X-ray diffraction analysis.
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