Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 13, Pages 3774-3780Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201001795
Keywords
DNA; fluorescent probes; nanoclusters; silver; template synthesis
Categories
Funding
- NSFC [20831003, 90813001, 20833006, 90913007, 21072182]
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Precise organization of metallic nanoclusters on DNA scaffolds holds great interest for nanopatterned materials that may find uses in electronics, sensors, medicine, and many other fields. Herein, we report the site-specific growth of fluorescent silver nanoclusters by using a mismatched double-stranded DNA template. Few-atom, molecular-scale Ag clusters are found to localize at the mismatched site and the metallized DNA retains its integrity. The DNA-encapsulated nanoclusters can be utilized as functional biological probes to identify single-nucleotide polymorphisms by taking advantage of the very bright fluorescence and excellent photostability of the nanoclusters. This approach offers the possibility of constructing novel DNA-based nanomaterials and nanomechanical devices with more sophisticated functions and will be highly beneficial in future biochemical, pharmaceutical, nanomechanical, and electronic applications.
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