Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 29, Pages 8139-8144Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201003247
Keywords
arginine; benzamides; galectins; molecular recognition; structure-activity relationships
Categories
Funding
- Swedish Strategic Research Foundation
- Royal Physiographic Society in Lund
- foundation Olle Engkvist Byggmastare
Ask authors/readers for more resources
Two series of C3-benzamido and O2-anion-substituted galactopyranosides were synthesized and studied as binders to arginine-rich proteins galectin-1, -3, -7, -8N (N-terminal domain), and -9N (N-terminal domain). The first series had a 4-methylbenzamide at C3 and the anionic O2-substituent was varied. The second series varied the 4-substituent of the C3-benzamide, whereas the anionic O2 substituent was kept as a sulfate. The influence of the O2-anion substituent correlated negatively with the oxygen charge density in case of galectin-1, -3, and -9N. In the second series, the electron-donating capacity of the 4-substituent of the C3-benzamides correlated positively with the magnitude of the affinity enhancement by the 2O-sulfate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available