Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 31, Pages 8596-8603Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201100715
Keywords
biomimetic synthesis; catecholates; siderophores; surface chemistry; synthetic methods
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By following a biomimetic design principle, tetravalent scaffolds based on an adamantyl and trisalkylmethyl core structure have been synthesized. These scaffolds have been coupled to three catecholamines, thus resembling the characteristic tripodal recognition motif of many natural metal binders, such as mussel adhesion proteins and siderophores, for example, enterobactin. Besides this tripodal recognition element, our scaffolds provide a fourth position for the conjugation of effector molecules. These effectors can be conjugated through biocompatible conjugation techniques to the scaffold and can be used to tailor the properties of different metal surfaces for a range of applications, for example, in implant engineering. Herein, we describe the synthesis of several tripodal metal binders and their immobilization on TiO2 surfaces by using a simple dip-coating procedure. Furthermore, we demonstrate the conjugation of our surface binders to the dye eosin Y as an effector molecule by peptide coupling. The resulting surfaces have been analyzed by using ellipsometry, time-of-flight secondary ion mass spectrometry, IR spectroscopy, and contact-angle measurements to confirm the specific loading on TiO2 films and nanoparticles with our trivalent surface binders. As a proof of concept, we have demonstrated the functionalization of TiO2 nanoparticles with the eosin Y dye.
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