Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 45, Pages 12544-12555Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201101508
Keywords
amination; cross-coupling; nitrogen heterocycles; regioselectivity; synthetic methods
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Funding
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/63407/2009, PTDC/QUI/65187/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63407/2009, PTDC/QUI/65187/2006] Funding Source: FCT
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1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions.
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