Journal
JOURNAL OF HEPATOLOGY
Volume 63, Issue 3, Pages 733-742Publisher
ELSEVIER
DOI: 10.1016/j.jhep.2015.05.027
Keywords
Liver intravital microscopy; Liver immunology; In vivo imaging; Sterile injury; Liver infection
Categories
Funding
- CAPES
- CNPq
- FAPERJ
- FAPEMIG/PRONEX
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The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as disease tolerance. The multiple hepatic cell populations are organized in a vascular environment that promotes intimate cellular interactions, including initiation of innate and adaptive immune responses, rapid leukocyte recruitment, pathogen clearance and production of a variety of immune mediators. In this review, we focus on the advances in liver immunology supported by intravital microscopy in diseases such as isquemia/reperfusion, acute liver injury and infections. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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