Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 16, Issue 36, Pages 10920-10928Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201000884
Keywords
cancer; multifunctional agents; redox chemistry; selenium; tellurium
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Funding
- University of Saarland
- Ministry of Economics and Science of Saarland
- Deutsche Forschungsgemeinschaft (DFG) [JA1741/2-1]
- European Community [FP7/2007-2013, 215009]
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Various human diseases, including different types of cancer, are associated with a disturbed intracellular redox balance and oxidative stress (OS). The past decade has witnessed the emergence of redox-modulating compounds able to utilize such pre-existing disturbances in the redox state of sick cells for therapeutic advantage. Selenium- and tellurium-based agents turn the oxidizing redox environment present in certain cancer cells into a lethal cocktail of reactive species that push these cells over a critical redox threshold and ultimately kill them through apoptosis. This kind of toxicity is highly selective: normal, healthy cells remain largely unaffected, since changes to their naturally low levels of oxidizing species produce little effect. To further improve selectivity, multifunctional sensor/effector agents are now required that recognize the biochemical signature of OS in target cells. The synthesis of such compounds provides interesting challenges for chemistry in the future.
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