Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 1, Pages 259-264Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002345
Keywords
carbamates; carbon dioxide fixation; fatty acids; isotope labeling; ureas
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Carbon-11 labeled isocyanates are efficiently prepared by dehydration of [C-11]carbamate salts, which in turn are easily formed from cyclotron-produced [C-11]CO2 and amines in the presence of a CO2 fixation agent. The [C-11]isocyanates are useful radio-synthons for the synthesis of a variety of [carbonyl-C-11]-labeled asymmetrical ureas and carbamate esters. The method is well suited to incorporate any isotope of carbon, and is especially useful for positron emission tomography (PET) radiotracers for in vivo imaging. This is demonstrated by using the method to make [carbonyl-C-11]-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase.
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