Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 16, Issue 41, Pages 12342-12348Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201002147
Keywords
flow chemistry; IR spectroscopy; microreactors; solid-phase synthesis
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Funding
- Royal Society
- Cambridge Overseas Trust
- BP endowment
- AstraZeneca
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This article describes the design, optimisation and development of a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, a potent delta-opioid receptor agonist developed by AstraZeneca. The process employs a sequence of flow-based microreactors, with integrated purification employing solid-supported reagents and in-line IR analytical protocols using a newly developed ReactIR flow cell. With this monitoring device, initiation of the fourth input flow stream can be precisely controlled during the synthesis.
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