Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 17, Issue 3, Pages 895-904Publisher
WILEY-BLACKWELL
DOI: 10.1002/chem.201002402
Keywords
cancer; FR901464; meayamycin; natural products; structure-activity relationships
Categories
Funding
- University of Pittsburgh
- Arnold and Mabel Beckman Scholar Award
- Averill Scholarship
- NIH [S10RR017977-01]
- US National Cancer Institute [R01 CA120792]
- NATIONAL CANCER INSTITUTE [R01CA120792] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR017977] Funding Source: NIH RePORTER
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FR901464, a natural product isolated from a bacterium source, activates a reporter gene, inhibits pre-mRNA splicing, and shows antitumor activity. We previously reported the development of a more potent analogue, meayamycin, through the total synthesis of FR901464. Herein, we report detailed structure-activity relationships of FR901464 that revealed the significance of the epoxide, carbon atoms in the tetrahydropyran ring, the Z geometry of the side chain, the 1,3-diene moiety, the C4-hydroxy group, and the C2 ''-carbonyl group. Importantly, the methyl group of the acetyl substituent was found to be inessential, leading to a new potent analogue. Additionally, partially based on in vivo data, we synthesized and evaluated potentially more metabolically stable analogues for their antiproliferative activity. These structural insights into FR901464 may contribute to the simplification of the natural product for further drug development.
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