Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 15, Issue 6, Pages 1300-1308Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802140
Keywords
cyclization; diversity-oriented synthesis; heterocycles; molecular diversity; multicomponent reactions
Categories
Funding
- National Institutes of Health [25439]
- Merck Research Laboratories
- Robert A. Welch Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM025439] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available