Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 15, Issue 15, Pages 3790-3799Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802318
Keywords
alkylation; amines; iridium; P,N ligands
Categories
Funding
- NanoCat an International Graduate Program
Ask authors/readers for more resources
A P,N-ligand-coordinated iridium complex has been employed as an efficient catalyst for the selective monoalkylation of (hetero)aromatic amines with alcohols. A significant improvement of this alkylation method has been achieved, such that it can be performed at a temperature of 70 degrees C and with catalyst loadings as low as 0.1 mol% Ir, while still affording excellent yields of secondary amines. Furthermore, the high selectivity of this catalyst for the monoalkylation of aromatic amino functions has been successfully exploited for the alkylation of diamines in both symmetric and non-symmetric fashions, providing a novel and very efficient synthetic tool for the preparation of N,N'-dialkylated aromatic diamines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available