Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 15, Issue 44, Pages 11784-11800Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200900049
Keywords
antimicrobial polymers; cell-penetrating peptides; ring-opening metathesis polymerization; peptidomimetics; vesicles
Categories
Funding
- ARO
- MRSEC
- NIH
- ONR
- German Research Foundation (DFG-Forschungsstipendium to K.L.)
Ask authors/readers for more resources
Natural macromolecules exhibit an extensive arsenal of properties, many of which have proven difficult to recapitulate in simpler synthetic systems. Over the last couple of years, foldamers have emerged as one important step toward increased functionality in synthetic systems. While the great majority of work in this area has focused on folded structures, hence the name, more recent progress has centered on polymers that mimic protein function. These efforts have resulted in the design of relatively simple macromolecules; one example are the synthetic mimics of antimicrobial peptides (SMAMPs) that capture the central physicochemical features of their natural archetypes irrespective of the specific folded form. Here we present our recent efforts to create polymers which display biological activity similar to natural proteins, including antimicrobial and cell-penetrating peptides.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available