Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 15, Issue 8, Pages 1816-1820Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200802074
Keywords
chromogenic sensors; heparin; hybrid materials; ion channels; molecular recognition
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Funding
- Ministerio de Ciencia y Tecnologia [CTQ200615456-CO4-01]
- Ministerio de Ciencia e Innovacion
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Heparin detective: Silica nanoparticles functionalised with ion-channel scaffolds were prepared and used for the chromofluorogenic sensing of heparin in aqueous environments (see figure). The surface of the nanoparticles was functionalised with polyamines (binding sites) and thiols. The reaction of a dye (squaraine) with the surface thiol groups was selectively inhibited by the coordination of heparin with the partly protonated polyamines.
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