Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 15, Issue 32, Pages 8037-8048Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200900185
Keywords
foldamers; nanofibers; oxazolidin-2-ones; self-assembly; anti-parallel beta sheet
Categories
Funding
- Ministero dell'Universita e della Ricerca Scientifica
- Universita di Bologna [SFB 610, HO 2346/1-3]
- Fondazione del Monte di Bologna e di Ravenna
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A series of oligomers of the type Boc-(L-Phe-D-Oxd)(n)-OBn (Boc = tert-butoxycarbonyl; Oxd=4-methyl-5-carboxy oxazolidin-2-one-, Bn = benzyl) were prepared for n = 2-5. The shortest oligomer, Boc-(L-Phe-D-Oxd)(2)- OBn, aggregates and forms a fiber-like material with an anti-parallel beta-sheet structure in which the oligopeptide units are connected to each other by only one intermolecular hydrogen bond. The longer oligomers exhibit structural heterogeneity. They start to organize into secondary structures by the formation of intramolecular hydrogen bonds at the pentamer level. Microscopy and diffraction of file oligomers indicated a crystalline character for only the shorter ones.
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