Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 14, Issue 19, Pages 5974-5980Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800012
Keywords
nanotubes; peptides; reversible transitions; self-assembly; vesicle-like structures
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Peptide-based self-assembling systems are increasingly attractive because of their wide range of applications in different fields. Peptide nanostructures are flexible with changes in the ambient conditions. Herein, a reversible shape transition between self-assembled dipeptide nanotubes (DPNTs) and vesicle-like structures is observed upon a change in the peptide concentration. SEM, TEM, AFM, and CD spectroscopy were used to follow this transition process. We show that dilution of a peptide-nanotube dispersion solution results in the formation of vesicle-like structures, which can then be reassembled into the nanotubes by concentrating the solution. A theoretical model describing this shape-transition phenomenon is presented to propose ways to engineer assembling molecules in order to devise other systems in which the morphology can be tuned on demand.
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