Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 14, Issue 34, Pages 10745-10761Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200801419
Keywords
amino acids; biological activity; drug design; medicinal chemistry; structure-activity relationships
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Funding
- NCSU
- Agile Sciences
- University of North Carolina Competitiveness Research Fund
- Robert Proctor Undergraduate Research Scholarship
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A second-generation library of 2-aminoimidazole-based derivatives incorporating a reversed amide (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. Most notably, an in-depth activity profile is reported for the most active subclass of derivatives that bear linear aliphatic chains off the amide bond. Additionally, further structural modifications of the core template, such as removal of the amide bond or substitution with a triazole isostere, resulted in the discovery of analogues with antibiofilm activities that varied with respect to their inhibition and dispersal properties of P. aeruginosa and A. baumannii biofilms.
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