Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 14, Issue 29, Pages 8892-8897Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200801090
Keywords
biological activity; fullerenes; liposomes; photochemistry; photodynamic activity
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Water-soluble fullerenes have attracted attention compounds that have been used to forge new paths in the field of photobiochemistry. To prepare water-soluble fullerenes, we employed lipid-membrane-incorporated fullerenes (LMICx;,; x=60 or 70) by using the fullerene exchange method from a gamma-cyclodextrin (gamma-CD) cavity to vesicles. LMIC60 have low toxicity in the dark and engender cell death by photoirradiation (lambda> 350 nm). Furthermore, the photodynamic activity of LMIC70 is 4.7-fold that of LMIC60 for the same photon flux (lambda >400nm). One of the reasons for the higher phototoxicity of LMIC70 is the higher generation of singlet oxygen (O-1(2)) in LMIC70 than in LMIC60. The difference between LMIC60 and LMIC70 is considered to be simply derived from the amount of light absorption in the 400-700nm region that is suitable for photodynamic therapy (PDT). To the best of our knowledge, this is the first case in which biological activity Of CM and its derivatives toward HeLa cells has been assayed.
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