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Dendrimers and DNA: Combinations of two special topologies for nanomaterials and biology

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 14, Issue 25, Pages 7422-7432

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800584

Keywords

biology; dendrimers; DNA; nanomaterials; self-assembly

Funding

  1. Agence Nationale de la Recherche [ANR-06-PCVI-0014]
  2. CNRS

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Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).

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