Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 54, Issue 5, Pages 926-929Publisher
SPRINGER
DOI: 10.1007/s10600-018-2514-9
Keywords
5 alpha-steroids; synthesis; hydrazones; pyrazolines; cytotoxic and antibacterial activity
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Funding
- Shota Rustaveli National Science Foundation (SRNSF) of Georgia [217560]
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Steroidal hydrazones and pyrazolines were synthesized via condensation of a series of 5 alpha-steroidal ketones with several hydrazines. Their cytotoxic activity against cancer cultures (A549 lung cancer, DLD-1 colorectal cancer, and WS1 normal skin fibroblasts) and antibacterial activity against E. coli and S. aureus strains were studied. The structures of the synthesized compounds were elucidated using PMR, C-13 NMR, and mass spectra.
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