Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 50, Issue 4, Pages 617-620Publisher
SPRINGER
DOI: 10.1007/s10600-014-1037-2
Keywords
gorgonian-derived fungus; Aspergillus sp.; anthraquinone; cytotoxic activity
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Funding
- National Natural Science Foundation of China [41130858, 81172977, 41176121]
- Program for New Century Excellent Talents in University, Ministry of Education of China [NCET-11-0472]
- Natural Science Foundation of Shandong Province [ZR2011DQ019, ZR2011HM085]
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One new anthraquinone derivative, named 8-O-methylnidurufin (1), together with five known analogues (2-6), have been isolated from a gorgonian-derived fungus, Aspergillus sp. The structures were elucidated by combined spectroscopic methods including 1D and 2D NMR spectral data. All isolated metabolites were evaluated for their cytotoxic and antibacterial activities in vitro. Compound 2 showed significant cytotoxic activity against K562 and HL-60 cell lines with IC50 values of 0.87 and 1.46 mu M, respectively.
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