Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 50, Issue 3, Pages 402-404Publisher
SPRINGER
DOI: 10.1007/s10600-014-0970-4
Keywords
acid; marine-derived Streptomyces; cytotoxicity; antibacterial activity
Categories
Funding
- Natural Science Foundation of China [21102020]
- National High Technology Research and Development Program (863 Program) of China [2011AA10A202-2]
- National Technologies RD Program [2011BAE06B04]
Ask authors/readers for more resources
One new polyunsaturated acid (1), together with two known compounds, benzodipyran (2) and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (3) were isolated from the fermentation broth of the marine Streptomyces violans (strain HTTA-F04129). Their structures were elucidated on the basis of 1D and 2D NMR, HR-FAB-MS spectra, and IR spectra. Bioassay results showed that compound 1 possessed significant selective antitumor activity against A2780 cell line in vitro with IC50 value 4.36 mu M and antibacterial activity against E. coli with MIC value of 25 mu g/mL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
