Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 49, Issue 5, Pages 799-802Publisher
SPRINGER
DOI: 10.1007/s10600-013-0751-5
Keywords
co-culture; marine mangrove fungus; polysubstituted benzaldehyde; antifungal activity
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Funding
- National Natural Science Foundation of China [21102049]
- Natural Science Foundation of Guangdong Province [9451064201003751]
- Science and technology project of Guangzhou City [11C12100771]
- Key Academic Program of the 3rd Phase 211 Project of South China Agricultural University [2009B010100001]
- Hesheng Zhujiang Innovation Experiment Program for University students [H11005]
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A new polysubstituted benzaldehyde derivative, ethyl 5-ethoxy-2-formyl-3-hydroxy-4-methylbenzoate (1), was isolated from the co-culture broth of two mangrove fungi (strains Nos. K38 and E33) isolated from the South China Sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, especially 2D NMR techniques. Primary bioassays showed that compound 1 at 0.25 mM inhibited Fusarium graminearum, Gloeosporium musae, Rhizoctonia solani Kuhn, and Phytophthora sojae (Kaufmann & Gerdemann) in 12.06, 11.57, 10.21, and 8.50 mm diameters, respectively.
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