Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 48, Issue 1, Pages 16-22Publisher
SPRINGER
DOI: 10.1007/s10600-012-0149-9
Keywords
aryl-3,4-dihydrocoumarin; 4-arylcoumarin; antimicrobial activity
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Funding
- Science and Technology Program of Guangdong Province
- Chinese Academy of Sciences
- Core Technology Program for Strategic Emerging Industries of Guangdong Province [2006B35604002, 2009B091300125, 2011A081401002]
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A new series of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins were synthesized by the reaction of substituted cinnamic acids and 3-arylpropiolic acid with the corresponding phenols. These compounds were evaluated for antibacterial activity in vitro. The synthesized compounds displayed different degrees of antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Bacillus dysenteriae, and Candida albicans (a fungus). Compounds with catechol moieties and 7,8-substituted dihydroxyls in the A ring were the most active antimicrobial agents.
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