Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 46, Issue 4, Pages 583-585Publisher
SPRINGER
DOI: 10.1007/s10600-010-9680-8
Keywords
Bacillus subtilis sp 13-2; cyclo(S-Pro-S-Phe); cyclo(R-Pro-S-Phe)
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Funding
- Ministry of Sciences and Technology of China [2010CB833801]
- Provincial Collaborative Foundation Project of Guangdong [9351007002000001, 2008A030203004]
- Chinese Academy of Sciences
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Two bioactive diketopiperazines, cyclo(S-Pro-S-Phe) and cyclo(R-Pro-S-Phe), against Bacillus subtilis (terrestrial), Staphylococcus aureus, and Escherichia coli DH5 alpha were isolated from marine surface sediment bacteria Bacillus subtilis sp. 13-2. To our knowledge, this was the first time that cyclo(S-Pro-S-Phe) and cyclo(R-Pro-S-Phe) were isolated from Bacillus subtilis, and the first time that cyclo(R-Pro-S-Phe) was isolated from a natural source. These two compounds were established on the basis of ESI-MS spectral data, as well as NMR 1D and 2D (COSY, HMQC, and HMBC) spectral data.
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