Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 46, Issue 2, Pages 230-232Publisher
SPRINGER
DOI: 10.1007/s10600-010-9576-7
Keywords
natural product; indene derivative; marine fungus; cytotoxic activity; prenyl; NMR assignment
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Funding
- National Natural Science Foundation of China [20772162, 20572136]
- 863 Foundation of China [2007AA09Z448, 2006AA09Z422]
- Science Foundation of Guangdong Province, China [2007A032600001]
- Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China
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A new indene derivative named phomoindene A (1) and four known compounds were isolated from the marine fungus Phomopsis sp. (No. GX7-4A). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR. Preliminary pharmacological tests revealed that phomoindene A exhibited little cytotoxic activity towards KB, KBv 200, and MCF-7 cell lines.
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