Journal
CHEMISTRY OF MATERIALS
Volume 26, Issue 5, Pages 1834-1847Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm403822w
Keywords
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Funding
- Sanofi
- CNRS
- French Ministry of Research
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Multifunctional poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) nanoparticles for cancer cell targeting and imaging have been designed by a combination of ring-opening polymerization and click chemistry. Nanoparticles containing both a targeting ligand and a fluorescent probe were prepared by blending PLA-b-PEG-ligand, PLA-b-PEG-fluorescent probe, and PLA-b-PEG-OMe copolymers at the molar ratios necessary to achieve the desired surface ligand and fluorescent probe densities. This strategy has been illustrated by the preparation of a large library of a variety of nanoparticles, such as ligand-decorated nanoparticles (with biotin, folic acid or anisamide), fluorescent nanoparticles (UV-vis or near-infrared dyes), and multifunctional nanoparticles decorated with a targeting ligand and a fluorescent probe. Successful targeting was demonstrated by surface plasmon resonance and in vitro experiments on different cancer cell lines.
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