Journal
CHEMISTRY OF MATERIALS
Volume 25, Issue 22, Pages 4585-4594Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm402776d
Keywords
rare-earth cations; cylindrical polymer brushes; template-directed; photoluminescence; paramagnetic; MRI contrast agent; cytotoxicity
Funding
- National Science Foundation of China [21374093]
- Alexander von Humboldt Foundation
- scholarship from the Elite Support Program of Bavaria.
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A novel template-directed approach based on core-shell cylindrical polymer brushes (CPBs) has been developed to prepare rare-earth metal cations (Ln(3+)) incorporated silica hybrid nanoparticles (NPs) with predictable dimensions. Tight chelation of Ln(3+) ions in the core of the CPB template and a cross-linked silica layer deposited on the shell provide a very stable encapsulation of Ln(3+) ions within the hybrid NPs and thus a high biocompatibility. As expected, the silica hybrid NPs obtain unique and diverse properties from the incorporated Ln(3+) ions. That is, the hybrid NPs with Tb3+ or Eu3+ incorporation exhibit characteristic photoluminescence in visible light range, while the Gd3+ - and Tb3+-containing hybrid NPs show paramagnetic behavior. Especially, the Gd3+-containing silica hybrid NPs show a remarkable longitudinal relaxation time (T-1) shortening effect as well as minimal cytotoxicity, suggesting the application potential of these NPs as effective magnetic resonance imaging (MRI) contrast agents. This novel template-directed approach succeeds in combining different functional centers via loading in situ mixed Ln(3+) ions (e.g. Tb3+ and GP(3+)) into individual CPBs resulting in multicomponent hybrid NPs, which possess both visible photoluminescence and T-1 contrast enhancement and can thus be applied as multimodal bioimaging probes.
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