Journal
CHEMISTRY OF MATERIALS
Volume 25, Issue 12, Pages 2503-2509Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm400812v
Keywords
Ag2Se quantum dot; near-infrared; fluorescence; in vivo imaging
Funding
- Chinese Academy of Science Bairen Ji Hua Program
- Chinese Academy of Science Strategic Priority Research Program [XDA01030200]
- Chinese Ministry of Science and Technology [2011CB965004]
- National Science Foundation of China [21073225]
- National Science Foundation of Jiangsu Province, China [BK2012007]
- CAS/SAFEA International Partnership Program for Creative Research Teams
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A facile solvothermal method is reported to synthesize highly photoluminescent Ag2Se quantum dots (QDs) with emission at 1300 nm in the second near-infrared window. After surface modification of C18-PMH-PEG, the Ag2Se QDs possess bright photoluminescence, good water-solubility, high colloidal stability and photostability, as well as decent biocompatibility, which are further successfully performed in in vivo deep imaging of organs and vascular structures with high spatial resolution. This new NIR-II fluorescent nanoprobe with small sizes, ideal optical properties, and decent biocompatibility opens up exciting opportunities for future biomedical applications.
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